Molecular basis of complement C3 deficiency in guinea pigs.
نویسندگان
چکیده
منابع مشابه
Molecular basis of complement C3 deficiency in guinea pigs.
In experiments to ascertain the biochemical basis of a genetically determined deficiency of the third component of complement (C3) in guinea pigs, we found that C3-deficient liver and peritoneal macrophages contain C3 messenger RNA of normal size (approximately 5 kb) and amounts, that this mRNA programs synthesis of pro-C3 in oocytes primed with liver RNA and in primary macrophage cultures. In ...
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Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether serum C3 and C4 complement change in adult nonpregnant female with iron deficient anemia or ...
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background and objectives: complement proteins are some of the most important plasma proteins of the innate immune system. impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. this study was conducted to show whether serum c3 and c4 complement change in adult nonpregnant female with iron deficient anemia or ...
متن کاملSerum Complement in Relation to Vitamin-C Deficiency in Guinea-Pigs
diet. Accordingly, we wished to study the changes of serum complement, if any, in vitamin-C deficiency in relation to sex and to the state of pregnancy. Thus, three groups of guinea-pigs consisting of male, female (nonpregnant) and female (pregnant) were chosen. The titration values of the complement of the guinea-pigs were obtained when the animals were on normal diet (gram and green grass). T...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1990
ISSN: 0021-9738
DOI: 10.1172/jci114721